Proniosomal gel-derived niosomes: an approach to sustain and improve the ocular delivery of brimonidine tartrate; formulation, in-vitro characterization, and in-vivo pharmacodynamic study.

Emad Eldeeb, Alaa; Salah, Salwa; Ghorab, Mahmoud

Emad Eldeeb, Alaa; Salah, Salwa; Ghorab, Mahmoud.

Affiliation

Emad Eldeeb A; a Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy , Cairo University , Cairo , Egypt.
Salah S; a Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy , Cairo University , Cairo , Egypt.
Ghorab M; a Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy , Cairo University , Cairo , Egypt.

Drug Deliv ; 26(1): 509-521, 2019 Dec.

Article in En | MEDLINE | ID: mdl-31090464

Subject(s)

Brimonidine Tartrate/administration & dosage; Brimonidine Tartrate/pharmacology; Drug Delivery Systems/methods; Eye/drug effects; Gels/chemistry; Intraocular Pressure/drug effects; Animals; Brimonidine Tartrate/toxicity; Drug Compounding; Eye/metabolism; Glaucoma/drug therapy; Liposomes; Male; Particle Size; Rabbits; Surface Properties

Key words

Glaucoma; brimonidine tartrate; proniosomal gel; sustained ocular delivery; tonometer

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Delivery Systems / Eye / Brimonidine Tartrate / Gels / Intraocular Pressure Limits: Animals Language: En Journal: Drug Deliv Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2019 Document type: Article Affiliation country: Egypt Country of publication: United kingdom

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