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Phantom Perception of Sound and the Abnormal Cortical Inhibition System: An Electroencephalography (EEG) Study.
Kyong, Jeong-Sug; Noh, Tae-Soo; Park, Moo Kyun; Oh, Seung-Ha; Lee, Jun Ho; Suh, Myung-Whan.
Affiliation
  • Kyong JS; 1 Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Korea.
  • Noh TS; 2 Audiology Institute, Department of Audiology and Speech-Language Pathology, Hallym University of Graduate Studies, Seoul, Korea.
  • Park MK; 1 Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Korea.
  • Oh SH; 1 Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Korea.
  • Lee JH; 1 Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Korea.
  • Suh MW; 1 Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Korea.
Ann Otol Rhinol Laryngol ; 128(6_suppl): 84S-95S, 2019 Jun.
Article in En | MEDLINE | ID: mdl-31092043
OBJECTIVES: Despite no observable external sound present, a perceived feeling of a recurrent unpleasant sound is a main complaint in the patients with chronic tinnitus. This phantom perception of sound is considered as the auditory equivalent of phantom limb pain, and altered excitability may be involved in its underlying pathology. Tinnitus-related hyper-excitation is suppressed by inhibitory repetitive transcranial magnetic stimulation (rTMS). However, the neural mechanism underlying the treatment is not fully understood, and quantifying the suppression induced by rTMS has yet to be considered. METHODS: We evaluated the effect of rTMS on the cortical inhibition status following single-site stimulation over the auditory temporal cortex (T group) or dual-site stimulation over the auditory temporal and the frontal regions (TF group). These effects were also compared with outcomes following sham stimulation (S group). Subjective response was recorded using tinnitus-related handicap index (THI), and changes in the cortical inhibition status were assessed using an auditory paired-pulse suppression index (PPSI). RESULTS: TF group showed the greatest benefit from the treatment evidenced in the reduced PPSI and THI scores. T and S groups did not benefit much. TF group overlapped mostly with the responder group, indicating improvement in both subjective THI and objective PPSI measurements. CONCLUSION: Our results suggest that rTMS is a beneficial therapeutic treatment for chronic tinnitus patients and the dual-site treatment was the most effective in terms of both tinnitus complaint and quantitative indices. Thus, subjective reports and electrophysiological signatures may be complementary for the diagnosis/prognosis of tinnitus.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Auditory Cortex / Auditory Perception / Tinnitus / Transcranial Magnetic Stimulation Type of study: Clinical_trials / Prognostic_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Ann Otol Rhinol Laryngol Year: 2019 Document type: Article Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Auditory Cortex / Auditory Perception / Tinnitus / Transcranial Magnetic Stimulation Type of study: Clinical_trials / Prognostic_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Ann Otol Rhinol Laryngol Year: 2019 Document type: Article Country of publication: United States