Your browser doesn't support javascript.
loading
Hyperthermia Suppresses Post - In Vitro Proliferation and Tumor Growth in Murine Malignant Melanoma and Colon Carcinoma.
Mantso, Theodora; Vasileiadis, Stavros; Lampri, Evangeli; Botaitis, Sotiris; Perente, Sebachedin; Simopoulos, Constantinos; Chlichlia, Katerina; Pappa, Aglaia; Panayiotidis, Mihalis I.
Affiliation
  • Mantso T; Department of Applied Sciences, Northumbria University, Newcastle Upon Tyne, U.K.
  • Vasileiadis S; School of Life Sciences, Heriot Watt University, Edinburgh, U.K.
  • Lampri E; Department of Obstetrics and Gynecology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
  • Botaitis S; Department of Pathology, University of Ioannina, Ioannina, Greece.
  • Perente S; First Department of Surgery, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
  • Simopoulos C; First Department of Surgery, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
  • Chlichlia K; Second Department of Surgery, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
  • Pappa A; Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis, Greece.
  • Panayiotidis MI; Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis, Greece.
Anticancer Res ; 39(5): 2307-2315, 2019 May.
Article in En | MEDLINE | ID: mdl-31092422
BACKGROUND: Several studies have highlighted hyperthermia's ability to enhance the effectiveness of radiation and chemotherapy in various in vitro and in vivo cancer models. MATERIALS AND METHODS: In vivo murine models of malignant melanoma and colon carcinoma were utilized for demonstrating hyperthermia's therapeutic effectiveness by examining levels of caspase 3, COX-2 and phospho-H2A.X (Ser139) as endpoints of apoptosis, proliferation and DNA damage respectively. RESULTS: Hyperthermia induced in vitro cytotoxicity in malignant melanoma (B16-F10) and colon carcinoma (CT26) cell lines. In addition, it reduced post-in vitro proliferation and suppression of tumor growth by inducing the expression of caspase-3 and phospho-H2A.X (Ser139) while reducing the expression of COX-2 in both murine cancer models. CONCLUSION: Hyperthermia can exert therapeutic effectiveness against melanoma and colon carcinoma by inhibiting a number of critical cellular cascades including apoptosis, proliferation and DNA damage.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Melanoma, Experimental / Colonic Neoplasms / Hyperthermia, Induced / Melanoma Limits: Animals / Humans Language: En Journal: Anticancer Res Year: 2019 Document type: Article Country of publication: Greece
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Melanoma, Experimental / Colonic Neoplasms / Hyperthermia, Induced / Melanoma Limits: Animals / Humans Language: En Journal: Anticancer Res Year: 2019 Document type: Article Country of publication: Greece