Shifting Paradigms in Allergic Contact Dermatitis: The Role of Innate Immunity.
J Invest Dermatol
; 140(1): 21-28, 2020 01.
Article
in En
| MEDLINE
| ID: mdl-31101475
ABSTRACT
The role of the innate immune system in allergic contact dermatitis (ACD) has traditionally been confined to the initial antigen sensitization phase. However, more recent findings have shown the role of innate immunity in additional aspects of ACD, including the effector phase of the classic type IV hypersensitivity reaction. As a result, the precise immunologic mechanisms mediating ACD are more complex than previously believed. The aim of this review is to provide insight into recent advances in understanding the role of the innate immune system in the pathogenesis of ACD, including novel mechanistic roles for macrophages, innate lymphoid cells, natural killer cells, innate γδ T cells, and other signaling molecules. These insights provide new opportunities for therapeutic intervention in ACD.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Killer Cells, Natural
/
Lymphocytes
/
T-Lymphocytes
/
Dermatitis, Allergic Contact
/
Macrophages
Limits:
Humans
Language:
En
Journal:
J Invest Dermatol
Year:
2020
Document type:
Article
Affiliation country:
United States