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Applications of MALDI mass spectrometry imaging for pharmacokinetic studies during drug development.
Nishidate, Masanobu; Hayashi, Mitsuhiro; Aikawa, Hiroaki; Tanaka, Kouji; Nakada, Naoyuki; Miura, Shin-Ichi; Ryu, Shoraku; Higashi, Tatsuya; Ikarashi, Yoshinori; Fujiwara, Yasuhiro; Hamada, Akinobu.
Affiliation
  • Nishidate M; Clinical Pharmacology Dept., Chugai Pharmaceutical Co., Ltd., 200 Kajiwara, Kamakura-shi, Kanagawa, 247-8530, Japan.
  • Hayashi M; Division of Molecular Pharmacology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
  • Aikawa H; Division of Molecular Pharmacology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
  • Tanaka K; DMPK Research Laboratories, Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 2-2-50 Kawagishi, Toda-shi, Saitama, 335-8505, Japan.
  • Nakada N; Analysis & Pharmacokinetics Research Labs., Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka Tsukuba-shi, Ibaraki, 305-8585, Japan.
  • Miura SI; External Affairs Department, Daiichi Sankyo Co., Ltd., 3-5-1, Nihonbashi-honcho, Chuo-ku, Tokyo, 103-8426, Japan.
  • Ryu S; Division of Molecular Pharmacology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
  • Higashi T; Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda-shi, Chiba, 278-8510, Japan.
  • Ikarashi Y; Office of New Drug V, Pharmaceuticals and Medical Devices Agency, 3-2-2, Kasumigaseki, Chiyoda-ku, Tokyo, 100-0013, Japan.
  • Fujiwara Y; Strategic Planning Bureau, National, Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
  • Hamada A; Division of Molecular Pharmacology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan; Department of Pharmacology and Therapeutics, Fundamental Innovative Oncology Core, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
Drug Metab Pharmacokinet ; 34(4): 209-216, 2019 Aug.
Article in En | MEDLINE | ID: mdl-31101590
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pharmacokinetics / Pharmaceutical Preparations / Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Drug Development Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Drug Metab Pharmacokinet Journal subject: FARMACOLOGIA / METABOLISMO Year: 2019 Document type: Article Affiliation country: Japan Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pharmacokinetics / Pharmaceutical Preparations / Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Drug Development Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Drug Metab Pharmacokinet Journal subject: FARMACOLOGIA / METABOLISMO Year: 2019 Document type: Article Affiliation country: Japan Country of publication: United kingdom