[Hemophagocytic lymphohistiocytosis with granulomatosis and diffuse T-cell infiltration associated with disseminated Nocardiosis and pulmonary infection due to Streptomyces spp]. / Syndrome d'activation macrophagique associé à une granulomatose et une infiltration lymphocytaire T CD4 diffuse révélant une nocardiose disséminée et une infection pulmonaire à Streptomyces spp.
Rev Med Interne
; 40(7): 457-461, 2019 Jul.
Article
in Fr
| MEDLINE
| ID: mdl-31103241
ABSTRACT
INTRODUCTION:
Hemophagocytic lymphohistiocytosis (HLH) is a rare syndrome frequently secondary to infectious disease, especially in immuno-compromised patients. We report a HLH secondary to disseminated nocardiosis and Streptomyces spp pulmonary infection. CASE REPORT A 69-years-old women had recent subcutaneous nodules of the forearms and loins associated with peripheral neuropathy and pulmonary nodule of the right upper lobe. Cutaneous biopsy revealed granuloma. Cutaneous lesions worsened and the patient developed a HLH with probable cardiac and neurological involvement, associated with cutaneous granulomatosis and diffuse polyclonal lymphocyte proliferation. Nocardia PCR was positive in cutaneous biopsy. Pulmonary samples revealed Streptomyces in culture and Nocardia in PCR. The evolution under antibiotic treatment was favorable.CONCLUSION:
Recent diagnosis of HLH without obvious etiology should lead to etiological investigation, including the search for infections with slow-growing bacteria such as Nocardia or Streptomyces spp.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Respiratory Tract Infections
/
Streptomyces
/
T-Lymphocytes
/
Granuloma, Respiratory Tract
/
Gram-Positive Bacterial Infections
/
Lymphohistiocytosis, Hemophagocytic
/
Nocardia
Type of study:
Diagnostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
Language:
Fr
Journal:
Rev Med Interne
Year:
2019
Document type:
Article