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Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression.
Lama, Lodoe; Adura, Carolina; Xie, Wei; Tomita, Daisuke; Kamei, Taku; Kuryavyi, Vitaly; Gogakos, Tasos; Steinberg, Joshua I; Miller, Michael; Ramos-Espiritu, Lavoisier; Asano, Yasutomi; Hashizume, Shogo; Aida, Jumpei; Imaeda, Toshihiro; Okamoto, Rei; Jennings, Andy J; Michino, Mayako; Kuroita, Takanobu; Stamford, Andrew; Gao, Pu; Meinke, Peter; Glickman, J Fraser; Patel, Dinshaw J; Tuschl, Thomas.
Affiliation
  • Lama L; Laboratory for RNA Molecular Biology, The Rockefeller University, 1230 York Ave, Box 186, New York, NY, 10065, USA.
  • Adura C; High-Throughput and Spectroscopy Resource Center, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.
  • Xie W; Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA.
  • Tomita D; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street 16th Floor, New York, NY, 10021, USA.
  • Kamei T; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street 16th Floor, New York, NY, 10021, USA.
  • Kuryavyi V; Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA.
  • Gogakos T; Laboratory for RNA Molecular Biology, The Rockefeller University, 1230 York Ave, Box 186, New York, NY, 10065, USA.
  • Steinberg JI; Laboratory for RNA Molecular Biology, The Rockefeller University, 1230 York Ave, Box 186, New York, NY, 10065, USA.
  • Miller M; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street 16th Floor, New York, NY, 10021, USA.
  • Ramos-Espiritu L; High-Throughput and Spectroscopy Resource Center, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.
  • Asano Y; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street 16th Floor, New York, NY, 10021, USA.
  • Hashizume S; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street 16th Floor, New York, NY, 10021, USA.
  • Aida J; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street 16th Floor, New York, NY, 10021, USA.
  • Imaeda T; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street 16th Floor, New York, NY, 10021, USA.
  • Okamoto R; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street 16th Floor, New York, NY, 10021, USA.
  • Jennings AJ; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street 16th Floor, New York, NY, 10021, USA.
  • Michino M; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street 16th Floor, New York, NY, 10021, USA.
  • Kuroita T; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street 16th Floor, New York, NY, 10021, USA.
  • Stamford A; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street 16th Floor, New York, NY, 10021, USA.
  • Gao P; Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA.
  • Meinke P; Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
  • Glickman JF; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street 16th Floor, New York, NY, 10021, USA.
  • Patel DJ; High-Throughput and Spectroscopy Resource Center, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA. fglickman@rockefeller.edu.
  • Tuschl T; Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA. pateld@mskcc.org.
Nat Commun ; 10(1): 2261, 2019 05 21.
Article in En | MEDLINE | ID: mdl-31113940
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enzyme Inhibitors / Drug Discovery / Nucleotidyltransferases Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2019 Document type: Article Affiliation country: United States
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enzyme Inhibitors / Drug Discovery / Nucleotidyltransferases Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2019 Document type: Article Affiliation country: United States