Homologous Recombination-Mediated DNA Repair and Implications for Clinical Treatment of Repair Defective Cancers.

Reilly, Nicole M; Yard, Brian D; Pittman, Douglas L

Reilly, Nicole M; Yard, Brian D; Pittman, Douglas L.

Affiliation

Reilly NM; Fondazione Piemontese per la Ricerca sul Cancro ONLUS, Candiolo, Italy.
Yard BD; Department of Translational Hematology and Oncology Research, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Pittman DL; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, USA. pittman@cop.sc.edu.

Methods Mol Biol ; 1999: 3-29, 2019.

Article in En | MEDLINE | ID: mdl-31127567

Subject(s)

DNA Breaks, Double-Stranded/drug effects; Neoplasms/drug therapy; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology; Recombinational DNA Repair/drug effects; DNA End-Joining Repair/genetics; Humans; Mutation; Neoplasms/genetics; Poly (ADP-Ribose) Polymerase-1/antagonists & inhibitors; Poly (ADP-Ribose) Polymerase-1/genetics; Poly (ADP-Ribose) Polymerase-1/metabolism; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use; Recombinational DNA Repair/genetics

Key words

Alternate end joining; Break induced replication; Chromosome integrity; Double-strand break repair; Homologous recombination; Nonhomologous end joining; PARP inhibitors; RAD51; Synthesis-dependent strand annealing; Ubiquitination

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Breaks, Double-Stranded / Recombinational DNA Repair / Poly(ADP-ribose) Polymerase Inhibitors / Neoplasms Limits: Humans Language: En Journal: Methods Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2019 Document type: Article Affiliation country: Italy Country of publication: United States

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