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Efficacy of a Multimechanistic Monoclonal Antibody Combination against Staphylococcus aureus Surgical Site Infections in Mice.
Ortines, Roger V; Wang, Yu; Liu, Haiyun; Dikeman, Dustin A; Pinsker, Bret L; Miller, Robert J; Kim, Sophia E; Ackerman, Nicole E; Rizkallah, Joe F; Marcello, LeeAnn T; Cohen, Taylor S; Tkaczyk, Christine; Sellman, Bret R; Miller, Lloyd S.
Affiliation
  • Ortines RV; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Wang Y; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Liu H; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Dikeman DA; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Pinsker BL; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Miller RJ; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Kim SE; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Ackerman NE; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Rizkallah JF; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Marcello LT; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Cohen TS; Department of Microbial Sciences, AstraZeneca, Gaithersburg, Maryland, USA.
  • Tkaczyk C; Department of Microbial Sciences, AstraZeneca, Gaithersburg, Maryland, USA.
  • Sellman BR; Department of Microbial Sciences, AstraZeneca, Gaithersburg, Maryland, USA.
  • Miller LS; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA lloydmiller@jhmi.edu.
Antimicrob Agents Chemother ; 63(8)2019 08.
Article in En | MEDLINE | ID: mdl-31138566
ABSTRACT
Surgical site infections (SSIs) are commonly caused by Staphylococcus aureus We report that a combination of three monoclonal antibodies (MEDI6389) that neutralize S. aureus alpha-toxin, clumping factor A, and four leukocidins (LukSF, LukED, HlgAB, and HlgCB) plus vancomycin had enhanced efficacy compared with control antibody plus vancomycin in two mouse models of S. aureus SSI. Therefore, monoclonal antibody-based neutralization of multiple S. aureus virulence factors may provide an adjunctive perioperative approach to combat S. aureus SSIs.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Staphylococcal Infections / Surgical Wound Infection / Anti-Bacterial Agents / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Animals Language: En Journal: Antimicrob Agents Chemother Year: 2019 Document type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Staphylococcal Infections / Surgical Wound Infection / Anti-Bacterial Agents / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Animals Language: En Journal: Antimicrob Agents Chemother Year: 2019 Document type: Article Affiliation country: United States