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Downregulation of LINC00515 in high-grade serous ovarian cancer and its relationship with platinum resistance.
Ni, Mao-Wei; Zhou, Jie; Zhang, Ying-Li; Zhou, Guo-Ming; Zhang, Sheng-Jie; Feng, Jian-Guo; Xu, Qiang; Zhou, Yun; Mou, Han-Zhou; Zheng, Zhi-Guo.
Affiliation
  • Ni MW; Zhejiang Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, PR China.
  • Zhou J; Key Laboratory Diagnosis & Treatment Technology on Thoracic Oncology of Zhejiang Province, Hangzhou, Zhejiang, PR China.
  • Zhang YL; Center for Medicinal Resources Research, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, Zhejiang, PR China.
  • Zhou GM; Department of Gynecologic Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, PR China.
  • Zhang SJ; Laboratory Medicine, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, PR China.
  • Feng JG; Zhejiang Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, PR China.
  • Xu Q; Zhejiang Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, PR China.
  • Zhou Y; Zhejiang Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, PR China.
  • Mou HZ; Zhejiang Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, PR China.
  • Zheng ZG; Zhejiang Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, PR China.
Biomark Med ; 13(7): 535-543, 2019 05.
Article in En | MEDLINE | ID: mdl-31140829
Aim: To investigate the expression of long intergenic noncoding RNA 00515 (LINC00515) in high-grade serous ovarian cancer (HGSOC) and its potential correlation with platinum resistance. Patients & methods: Expression of LINC00515 in HGSOC (n = 115) and normal (n = 19) tissues was detected via quantitative real-time PCR (qRT-PCR). We further explored the statistical significance of the relationship between LINC00515 expression and platinum resistance in HGSOC. Results: LINC00515 was gradually downregulated in the order of normal > platinum-sensitive > platinum-resistant tissue (p < 0.05). Results demonstrated that LINC00515 downregulation was correlated with platinum resistance and relapse-free survival (RFS) of HGSOC (p < 0.05). Conclusion: LINC00515 downregulation is correlated with HGSOC development, platinum resistance and RFS, supporting its utility as a potential biomarker to predict platinum resistance and prognosis of RFS.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Platinum / Down-Regulation / Drug Resistance, Neoplasm / RNA, Long Noncoding Type of study: Prognostic_studies Limits: Female / Humans / Middle aged Language: En Journal: Biomark Med Journal subject: BIOQUIMICA / MEDICINA Year: 2019 Document type: Article Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Platinum / Down-Regulation / Drug Resistance, Neoplasm / RNA, Long Noncoding Type of study: Prognostic_studies Limits: Female / Humans / Middle aged Language: En Journal: Biomark Med Journal subject: BIOQUIMICA / MEDICINA Year: 2019 Document type: Article Country of publication: United kingdom