Neoadjuvant conformal radiotherapy before liver transplantation for hepatocellular carcinoma: a propensity score matched analysis of postoperative morbidity and oncological results.
Future Oncol
; 15(21): 2517-2530, 2019 Jul.
Article
in En
| MEDLINE
| ID: mdl-31179766
ABSTRACT
Aim:
To assess neoadjuvant conformal radiotherapy (CRT) before orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC) not suitable for standard locoregional treatments.Methods:
Patients undergoing OLT for HCC with or without prior CRT were compared using 13 propensity score matching.Results:
After propensity score matching, 23 patients with CRT were compared with 66 control subjects. Severe morbidity rate was 34.8 versus 24.2% in the CRT and non-CRT groups (p = 0.289). Complete pathological response was observed in 47.8% of CRT-targeted nodules. The 1-/3-/5-year disease-free survivals were 77.3, 77.3 and 68.7% in the CRT group versus 85.4, 68.0 and 61.7% in the non-CRT group (p = 0.829).Conclusion:
Conformal radiotherapy represents a satisfactory neoadjuvant therapy for OLT candidates not suitable for standard HCC locoregional therapies.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Preoperative Care
/
Carcinoma, Hepatocellular
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Radiotherapy, Conformal
/
Liver Neoplasms
Type of study:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Future Oncol
Year:
2019
Document type:
Article
Affiliation country:
France