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The impact of skin care products on skin chemistry and microbiome dynamics.
Bouslimani, Amina; da Silva, Ricardo; Kosciolek, Tomasz; Janssen, Stefan; Callewaert, Chris; Amir, Amnon; Dorrestein, Kathleen; Melnik, Alexey V; Zaramela, Livia S; Kim, Ji-Nu; Humphrey, Gregory; Schwartz, Tara; Sanders, Karenina; Brennan, Caitriona; Luzzatto-Knaan, Tal; Ackermann, Gail; McDonald, Daniel; Zengler, Karsten; Knight, Rob; Dorrestein, Pieter C.
Affiliation
  • Bouslimani A; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, USA.
  • da Silva R; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, USA.
  • Kosciolek T; Department of Pediatrics, University of California, San Diego, La Jolla, CA, 92037, USA.
  • Janssen S; Department of Pediatrics, University of California, San Diego, La Jolla, CA, 92037, USA.
  • Callewaert C; Department for Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
  • Amir A; Department of Pediatrics, University of California, San Diego, La Jolla, CA, 92037, USA.
  • Dorrestein K; Center for Microbial Ecology and Technology, Ghent University, 9000, Ghent, Belgium.
  • Melnik AV; Department of Pediatrics, University of California, San Diego, La Jolla, CA, 92037, USA.
  • Zaramela LS; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, USA.
  • Kim JN; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, USA.
  • Humphrey G; Department of Pediatrics, University of California, San Diego, La Jolla, CA, 92037, USA.
  • Schwartz T; Department of Pediatrics, University of California, San Diego, La Jolla, CA, 92037, USA.
  • Sanders K; Department of Pediatrics, University of California, San Diego, La Jolla, CA, 92037, USA.
  • Brennan C; Department of Pediatrics, University of California, San Diego, La Jolla, CA, 92037, USA.
  • Luzzatto-Knaan T; Department of Pediatrics, University of California, San Diego, La Jolla, CA, 92037, USA.
  • Ackermann G; Department of Pediatrics, University of California, San Diego, La Jolla, CA, 92037, USA.
  • McDonald D; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, USA.
  • Zengler K; Department of Pediatrics, University of California, San Diego, La Jolla, CA, 92037, USA.
  • Knight R; Department of Pediatrics, University of California, San Diego, La Jolla, CA, 92037, USA.
  • Dorrestein PC; Department of Pediatrics, University of California, San Diego, La Jolla, CA, 92037, USA.
BMC Biol ; 17(1): 47, 2019 06 12.
Article in En | MEDLINE | ID: mdl-31189482
ABSTRACT

BACKGROUND:

Use of skin personal care products on a regular basis is nearly ubiquitous, but their effects on molecular and microbial diversity of the skin are unknown. We evaluated the impact of four beauty products (a facial lotion, a moisturizer, a foot powder, and a deodorant) on 11 volunteers over 9 weeks.

RESULTS:

Mass spectrometry and 16S rRNA inventories of the skin revealed decreases in chemical as well as in bacterial and archaeal diversity on halting deodorant use. Specific compounds from beauty products used before the study remain detectable with half-lives of 0.5-1.9 weeks. The deodorant and foot powder increased molecular, bacterial, and archaeal diversity, while arm and face lotions had little effect on bacterial and archaeal but increased chemical diversity. Personal care product effects last for weeks and produce highly individualized responses, including alterations in steroid and pheromone levels and in bacterial and archaeal ecosystem structure and dynamics.

CONCLUSIONS:

These findings may lead to next-generation precision beauty products and therapies for skin disorders.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin / Skin Care / Cosmetics / Microbiota Limits: Adult / Female / Humans / Male Language: En Journal: BMC Biol Journal subject: BIOLOGIA Year: 2019 Document type: Article Affiliation country: United States
Fulltext
Add to My VHL
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin / Skin Care / Cosmetics / Microbiota Limits: Adult / Female / Humans / Male Language: En Journal: BMC Biol Journal subject: BIOLOGIA Year: 2019 Document type: Article Affiliation country: United States