Effects of huoxin formula on the arterial functions of patients with coronary heart disease.
Pharm Biol
; 57(1): 13-20, 2019 Dec.
Article
in En
| MEDLINE
| ID: mdl-31199705
ABSTRACT
Context Huoxin formula is a Traditional Chinese Medicine for coronary heart disease (CHD) treatment. Objective:
To explore the therapeutic mechanism of the Huoxin formula on arterial functions in CHD patients. Materials andmethods:
Fifty-eight CHD patients receiving cardiovascular drugs including ß-receptor blocker, statins, and antiplatelet medications or others were randomized into intervention [additionally 13.5 g Huoxin formula granules dissolved in 150 mL warm water per time, twice a day (n = 30)] and control [only cardiovascular drugs (n = 28)] groups. Serum biomarkers (hs-CRP, IL-18, IL-17, TNF-α, MMP-9), and cardiovascular indicators of the common and internal carotid arteries (ICAs) were monitored before and after the treatments.Results:
After 3 months of treatment, the increases of intima-media thicknesses (IMT) of the left and right common carotid arteries (CCAs) as well as of the left and right ICAs and the increases of the left and right cardio-ankle vascular index were all significantly (all p < 0.001) less in the intervention than in control group (all p < 0.001). Serum concentrations reductions of hs-CRP, IL-18, IL-17 and MMP9 (all p < 0.001) levels were higher in the intervention compared to the control group, which correlated with the changes of left ICA (hs-CRP r = 0.581, p = 0.009; IL-18 r = 0.594, p = 0.007; IL-17 r = 0.575, p = 0.006). Discussion andconclusion:
Since the Huoxin formula improved arterial functions and reduced inflammatory factor activities in CHD patients, a large-scale clinical trial is warranted.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drugs, Chinese Herbal
/
Carotid Arteries
/
Cytokines
/
Coronary Disease
Type of study:
Clinical_trials
/
Diagnostic_studies
Limits:
Adult
/
Aged
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Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Pharm Biol
Year:
2019
Document type:
Article
Affiliation country:
China