Silent atrial fibrillation is associated with P-wave duration index in patients with cardiac resynchronisation therapy.

ABSTRACT

INTRODUCTION: Atrial fibrillation (AF) attacks can be silent, symptomatic, or emerge with its complications in pacemaker-implanted patient groups. P-wave duration index (PWDI), a novel parameter, is calculated by dividing the P-wave duration (PWD) by the PR interval. This study aimed to investigate the relation between PWDI and silent AF development in cardiac resynchronisation therapy defibrillator (CRT-D)-applied patients. MATERIAL AND METHODS: The study population consisted of 181 CRT-D device-implanted patients. Atrial fibrillation attacks that last at least 30 s with no symptoms were accepted as silent AF. RESULTS: Patients were separated into two groups "with silent AF" and "without silent AF". The without silent AF group comprised 121 patients (mean age 62.9 ±8.7 years, 62% male). The with silent AF group included 60 patients (mean age 67.9 ±9.7 years, 60% male). The silent AF group had significantly higher mean age (p = 0.001). PR duration was significantly higher in the without silent AF group (p = 0.001). Patients with first-degree IAB and PWDI values were significantly higher in the with silent AF group (p-values were 0.001 and < 0.001, respectively). Age (OR = 1.073, 95% CI 1.028-1.119, p = 0.001) and PWDI (OR = 1.053, 95% CI 1.028-1.078, p < 0.001) were detected as independent predictors for silent AF in the binomial logistic regression analysis. In the ROC analysis, a PWDI cut-off value of 0.67 determined silent AF with 81.7% sensitivity and 51.4% specificity (AUC = 0.701, p < 0.001). CONCLUSIONS: P-wave duration index was significantly associated with silent AF in patients with CRT-D.