Bioactivities of Natural Catalpol Derivatives.
Curr Med Chem
; 26(33): 6149-6173, 2019.
Article
in En
| MEDLINE
| ID: mdl-31218947
ABSTRACT
Catalpol, a famous molecule of iridoids, possesses extensive pharmacological activities. Our studies found that compounds with low-polarity substituents at the 6-O position of catalpol exhibited higher NF-κB inhibitory potency than catalpol. However, catalpol derivatives are not much focused. Here this review provides extensive coverage of naturally occurring catalpol derivatives discovered from 1888 until 2018. It covers their distribution, chemotaxonomic significance, chemical structures, and bioactivities from more than 200 peer-reviewed articles, and highlights the structure-activity relationship of catalpol derivatives.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Iridoid Glucosides
Limits:
Animals
/
Humans
Language:
En
Journal:
Curr Med Chem
Journal subject:
QUIMICA
Year:
2019
Document type:
Article
Affiliation country:
China