The people behind the papers - Eduardo Leyva-Díaz and Oliver Hobert.
Development
; 146(13)2019 06 21.
Article
in En
| MEDLINE
| ID: mdl-31227643
ABSTRACT
Transcriptional autoregulation occurs when transcription factors bind their own cis-regulatory sequences, ensuring their own continuous expression along with expression of other targets. During development, continued expression of identity-specifying transcription factors can be achieved by autoregulation, but until now formal evidence for a developmental requirement of autoregulation has been lacking. A new paper in Development provides this proof with the help of CRISPR/Cas9 gene editing in the C. elegans nervous system. We caught up with the paper's two authors postdoc Eduardo Leyva-Díaz and his supervisor Oliver Hobert, Professor of Biological Sciences and HHMI Investigator at Columbia University, New York, to find out more about the work.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Developmental Biology
/
Central Nervous System
/
Caenorhabditis elegans
/
Laboratory Personnel
/
CRISPR-Cas Systems
/
Gene Editing
Limits:
Animals
/
Humans
Country/Region as subject:
America do norte
Language:
En
Journal:
Development
Journal subject:
BIOLOGIA
/
EMBRIOLOGIA
Year:
2019
Document type:
Article