Phenolic constituents with neuroprotective activities from Hypericum wightianum.
Phytochemistry
; 165: 112049, 2019 Sep.
Article
in En
| MEDLINE
| ID: mdl-31229788
ABSTRACT
Five undescribed phenolic compounds, inclusing a depsidone derivative, hyperwightin A, a flavone derivative, hyperwightin B, and three benzophenone glycosides, hyperwightins C-E, along with four known ones were isolated from the 95% EtOH extract of the whole plants of Hypericum wightianum. Structures of the obtained compounds were elucidated by spectroscopic analyses. The protective effects of the isolates against corticosterone-induced PC12â¯cell injury were assessed. Hyperwightin E, petiolin G and hyperxanthone exhibited noticeable neuroprotection at 10⯵M.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenols
/
Neuroprotective Agents
/
Hypericum
/
Phytochemicals
/
Neuroprotection
Limits:
Animals
Language:
En
Journal:
Phytochemistry
Year:
2019
Document type:
Article