The deafness gene GSDME: its involvement in cell apoptosis, secondary necrosis, and cancers.
Naunyn Schmiedebergs Arch Pharmacol
; 392(9): 1043-1048, 2019 09.
Article
in En
| MEDLINE
| ID: mdl-31230091
ABSTRACT
Gasdermin E (GSDME), also called DFNA5, is a member of the gasdermin family. GSDME is involved in the regulation of apoptosis and necrosis. The N-terminal domain of GSDME displays an apoptosis-inducing activity while the C-terminal domain may serve as an apoptosis-inhibiting regulator by shielding the N-terminal domain. Besides its function in the regulation of apoptosis, GSDME was recently reported to be a substrate of caspase-3 and cleavage of GSDME by caspase-3 into necrotic N-terminal fragment leads to the induction of secondary necrosis. GSDME was first identified as a deafness gene because its mutation was associated with a specific form of autosomal dominant progressive sensorineural hearing loss. Furthermore, GSDME has been considered a tumor suppressor implicated in several types of cancer. This mini-review summarized recent reports relevant to the functions of GSDME in the regulation of apoptosis and necrosis as well as its clinical relevance.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, Estrogen
/
Deafness
/
Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
Naunyn Schmiedebergs Arch Pharmacol
Year:
2019
Document type:
Article
Affiliation country:
China