Inclusion Complexes of ß and HPß-Cyclodextrin with α, ß Amyrin and In Vitro Anti-Inflammatory Activity.
Biomolecules
; 9(6)2019 06 21.
Article
in En
| MEDLINE
| ID: mdl-31234312
ABSTRACT
α, ß amyrin (ABAM) is a natural mixture of pentacyclic triterpenes that has a wide range of biological activities. ABAM is isolated from the species of the Burseraceae family, in which the species Protium is commonly found in the Amazon region of Brazil. The aim of this work was to develop inclusion complexes (ICs) of ABAM and ß-cyclodextrin (ßCD) and hydroxypropyl-ß-cyclodextrin (HPßCD) by physical mixing (PM) and kneading (KN) methods. Interactions between ABAM and the CD's as well as the formation of ICs were confirmed by physicochemical characterization in the solid state by Fourier transform infrared (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD), thermogravimetry (TG) and differential scanning calorimetry (DSC). Physicochemical characterization indicated the formation of ICs with both ßCD and HPßCD. Such ICs were able to induce changes in the physicochemical properties of ABAM. In addition, the formation of ICs with cyclodextrins showed to be an effective and promising alternative to enhance the anti-inflammatory activity and safety of ABAM.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oleanolic Acid
/
2-Hydroxypropyl-beta-cyclodextrin
/
Anti-Inflammatory Agents
Limits:
Animals
Language:
En
Journal:
Biomolecules
Year:
2019
Document type:
Article
Affiliation country:
Brazil