Tolerability and surrogate efficacy parameters of a polymerized depot mixture pollen extracts without dilutional effect.
Immunotherapy
; 11(12): 1031-1042, 2019 08.
Article
in En
| MEDLINE
| ID: mdl-31234665
ABSTRACT
Aim:
To evaluate tolerability of subcutaneous immunotherapy, in a polymerized mixture (Olea europaea/Phleum pratense) depot presentation. Patients &methods:
A total of 47 poly-allergic patients received an abbreviated schedule with three injections at weekly intervals or a cluster schedule with two administrations in 1 day. Both treatments continued with 3 monthly maintenance administrations.Results:
Two systemic reactions, (4.3%). One grade 0 and one grade I. No local reactions. Immunoglobulin levels, increased significantly at final visit versus baseline in sIgG and sIgG4; in both schedules and allergens, no significant changes in specific immunoglobulin E levels were detected. Cutaneous reactivity at final visit decreased significantly.Conclusion:
Both administration schedules with polymerized mixture of O. europaea/P. pratense, presented an excellent tolerability profile and induced preliminary efficacy changes.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Asthma
/
Rhinitis, Allergic, Seasonal
/
Desensitization, Immunologic
Type of study:
Guideline
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Immunotherapy
Journal subject:
ALERGIA E IMUNOLOGIA
/
TERAPEUTICA
Year:
2019
Document type:
Article
Affiliation country:
Spain