PKR activation by noncanonical ligands: a 5'-triphosphate requirement versus antisense contamination.

Safran, Sarah A; Eckert, Debra M; Leslie, Evan A; Bass, Brenda L

Safran, Sarah A; Eckert, Debra M; Leslie, Evan A; Bass, Brenda L.

Affiliation

Safran SA; Department of Biochemistry, University of Utah, Salt Lake City, Utah 84112, USA.
Eckert DM; Department of Biochemistry, University of Utah, Salt Lake City, Utah 84112, USA.
Leslie EA; Department of Biochemistry, University of Utah, Salt Lake City, Utah 84112, USA.
Bass BL; Department of Biochemistry, University of Utah, Salt Lake City, Utah 84112, USA.

RNA ; 25(9): 1192-1201, 2019 09.

Article in En | MEDLINE | ID: mdl-31239298

Subject(s)

Enzyme Activation/genetics; Polyphosphates/metabolism; eIF-2 Kinase/genetics; eIF-2 Kinase/metabolism; DNA-Directed RNA Polymerases/metabolism; Dimerization; Humans; Ligands; Phosphorylation/genetics; Protein Binding/genetics; RNA, Double-Stranded/genetics; RNA, Small Nucleolar/genetics; Transcription, Genetic/genetics; Ultracentrifugation/methods; Viral Proteins/metabolism

Key words

PKR; T7 RNA polymerase; antisense; dsRNA; snoRNA; ss-dsRNA

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyphosphates / EIF-2 Kinase / Enzyme Activation Limits: Humans Language: En Journal: RNA Journal subject: BIOLOGIA MOLECULAR Year: 2019 Document type: Article Affiliation country: United States Country of publication: United States

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