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Low level of exosomal long non-coding RNA HOTTIP is a prognostic biomarker in colorectal cancer.
Oehme, Florian; Krahl, Stefan; Gyorffy, Balazs; Muessle, Benjamin; Rao, Venkatesh; Greif, Helena; Ziegler, Nicole; Lin, Kuailu; Thepkaysone, May-Linn; Polster, Heike; Tonn, Torsten; Schneider, Martin; Weitz, Juergen; Baenke, Franziska; Kahlert, Christoph.
Affiliation
  • Oehme F; Department for Visceral, Thoracic and Vascular Surgery, University Hospital Dresden , Dresden , Germany.
  • Krahl S; Department for Visceral, Thoracic and Vascular Surgery, University Hospital Dresden , Dresden , Germany.
  • Gyorffy B; MTA TTK Lendület Cancer Biomarker Research Group, Institute of Enzymology, Hungarian Academy of Sciences , Budapest , Hungary.
  • Muessle B; Department of Pediatrics, Semmelweis University , Budapest , Hungary.
  • Rao V; Department for Visceral, Thoracic and Vascular Surgery, University Hospital Dresden , Dresden , Germany.
  • Greif H; Department for Visceral, Thoracic and Vascular Surgery, University Hospital Dresden , Dresden , Germany.
  • Ziegler N; Department for Visceral, Thoracic and Vascular Surgery, University Hospital Dresden , Dresden , Germany.
  • Lin K; Department for Visceral, Thoracic and Vascular Surgery, University Hospital Dresden , Dresden , Germany.
  • Thepkaysone ML; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ) , Heidelberg , Germany.
  • Polster H; Department for Visceral, Thoracic and Vascular Surgery, University Hospital Dresden , Dresden , Germany.
  • Tonn T; Department for Visceral, Thoracic and Vascular Surgery, University Hospital Dresden , Dresden , Germany.
  • Schneider M; Department for Visceral, Thoracic and Vascular Surgery, University Hospital Dresden , Dresden , Germany.
  • Weitz J; Department for Transfusion Medicine, German Red Cross Blood Donation Service North-East , Dresden , Germany.
  • Baenke F; Department of General, Visceral and Transplantation Surgery, University of Heidelberg , Heidelberg , Germany.
  • Kahlert C; Department for Visceral, Thoracic and Vascular Surgery, University Hospital Dresden , Dresden , Germany.
RNA Biol ; 16(10): 1339-1345, 2019 10.
Article in En | MEDLINE | ID: mdl-31251124
Molecular risk stratification of colorectal cancer can improve patient outcome. A panel of lncRNAs (H19, HOTTIP, HULC and MALAT1) derived from serum exosomes of patients with non-metastatic CRC and healthy donors was analyzed. Exosomes from healthy donors carried significantly more H19, HULC and HOTTIP transcripts in comparison to CRC patients. Correlation analysis between lncRNAs and clinical data revealed a statistical significance between low levels of exosomal HOTTIP and poor overall survival. This was confirmed by multivariate analysis that HOTTIP is an independent prognostic marker for overall survival (HR: 4.5, CI: 1.69-11.98, p = 0.0027). Here, HOTTIP poses to be a valid biomarker for patients with a CRC to predict post-surgical survival time.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Biomarkers, Tumor / RNA, Long Noncoding Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: RNA Biol Journal subject: BIOLOGIA MOLECULAR Year: 2019 Document type: Article Affiliation country: Germany Country of publication: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Biomarkers, Tumor / RNA, Long Noncoding Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: RNA Biol Journal subject: BIOLOGIA MOLECULAR Year: 2019 Document type: Article Affiliation country: Germany Country of publication: United States