A 13-week subchronic toxicity study of vanillin propylene glycol acetal in F344 rats.

Matsushita, Kohei; Toyoda, Takeshi; Morikawa, Tomomi; Ogawa, Kumiko

Matsushita, Kohei; Toyoda, Takeshi; Morikawa, Tomomi; Ogawa, Kumiko.

Affiliation

Matsushita K; Division of Pathology, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki, Kanagawa, 210-9501, Japan.
Toyoda T; Division of Pathology, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki, Kanagawa, 210-9501, Japan. Electronic address: t-toyoda@nihs.go.jp.
Morikawa T; Division of Pathology, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki, Kanagawa, 210-9501, Japan.
Ogawa K; Division of Pathology, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki, Kanagawa, 210-9501, Japan.

Food Chem Toxicol ; 132: 110643, 2019 Oct.

Article in En | MEDLINE | ID: mdl-31252024

Subject(s)

Acetals/toxicity; Flavoring Agents/toxicity; Propylene Glycols/toxicity; Acetals/administration & dosage; Administration, Oral; Animals; Body Weight/drug effects; Female; Flavoring Agents/administration & dosage; Liver/drug effects; Liver/pathology; Male; No-Observed-Adverse-Effect Level; Organ Size/drug effects; Propylene Glycols/administration & dosage; Rats, Inbred F344

Key words

F344 rats; Flavoring agent; Hepatocellular hypertrophy; Subchronic toxicity; Vanillin propylene glycol acetal

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Propylene Glycols / Flavoring Agents / Acetals Limits: Animals Language: En Journal: Food Chem Toxicol Year: 2019 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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