Insights into the flexibility of the T3 loop and GTPase activating protein (GAP) domain of dimeric &#945; and ß tubulins from a molecular dynamics perspective.

C, Selvaa Kumar; Gadewal, Nikhil; Choudhary, Rajan Kumar; Dasgupta, Debjani

Insights into the flexibility of the T3 loop and GTPase activating protein (GAP) domain of dimeric α and ß tubulins from a molecular dynamics perspective.

C, Selvaa Kumar; Gadewal, Nikhil; Choudhary, Rajan Kumar; Dasgupta, Debjani.

Affiliation

C SK; School of Biotechnology and Bioinformatics, D.Y. Patil Deemed to be University, CBD Belapur, Navi Mumbai, India. Electronic address: selvaakumar.c@dypatil.edu.
Gadewal N; Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Kharghar, Navi Mumbai, India. Electronic address: ngadewal@actrec.gov.in.
Choudhary RK; Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Kharghar, Navi Mumbai, India.
Dasgupta D; School of Biotechnology and Bioinformatics, D.Y. Patil Deemed to be University, CBD Belapur, Navi Mumbai, India.

Comput Biol Chem ; 82: 37-43, 2019 Oct.

Article in En | MEDLINE | ID: mdl-31255973

Subject(s)

Tubulin/chemistry; Tubulin/metabolism; Amino Acid Sequence; Animals; Anisotropy; Binding Sites; Cattle; Glycine/chemistry; Molecular Dynamics Simulation; Mutation; Pliability; Protein Binding; Protein Conformation; Protein Domains; Protein Isoforms/chemistry; Protein Isoforms/genetics; Protein Isoforms/metabolism; Protein Multimerization; Sequence Alignment; Tubulin/genetics

Key words

GAP domain; GTP hydrolysis; Intermediate domain; T3 loop; T7 loop; Tubulin; helix H8

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tubulin Limits: Animals Language: En Journal: Comput Biol Chem Journal subject: BIOLOGIA / INFORMATICA MEDICA / QUIMICA Year: 2019 Document type: Article Country of publication: United kingdom

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