LC3-Associated Endocytosis Facilitates ß-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer's Disease.

Heckmann, Bradlee L; Teubner, Brett J W; Tummers, Bart; Boada-Romero, Emilio; Harris, Lacie; Yang, Mao; Guy, Clifford S; Zakharenko, Stanislav S; Green, Douglas R

Heckmann, Bradlee L; Teubner, Brett J W; Tummers, Bart; Boada-Romero, Emilio; Harris, Lacie; Yang, Mao; Guy, Clifford S; Zakharenko, Stanislav S; Green, Douglas R.

Affiliation

Heckmann BL; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Teubner BJW; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Tummers B; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Boada-Romero E; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Harris L; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Yang M; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Guy CS; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Zakharenko SS; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Green DR; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: douglas.green@stjude.org.

Cell ; 178(3): 536-551.e14, 2019 07 25.

Article in En | MEDLINE | ID: mdl-31257024

Subject(s)

Alzheimer Disease/pathology; Amyloid beta-Peptides/metabolism; Endocytosis; Microtubule-Associated Proteins/metabolism; Alzheimer Disease/metabolism; Animals; Autophagy-Related Protein 5/deficiency; Autophagy-Related Protein 5/genetics; Autophagy-Related Proteins/deficiency; Autophagy-Related Proteins/genetics; CD36 Antigens/metabolism; Cytokines/metabolism; Disease Models, Animal; Hippocampus/metabolism; Intracellular Signaling Peptides and Proteins/deficiency; Intracellular Signaling Peptides and Proteins/genetics; Membrane Glycoproteins/metabolism; Mice; Mice, Transgenic; Microglia/cytology; Microglia/metabolism; RAW 264.7 Cells; Receptors, Immunologic/metabolism; Toll-Like Receptor 4/metabolism

Key words

Alzheimer's Disease; LC3-associated endocytosis; LC3-associated phagocytosis; autophagy; microglia; neurodegeneration; neuroinflammation; receptor-mediated endocytosis; tau pathology; ß-amyloid

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Amyloid beta-Peptides / Endocytosis / Alzheimer Disease / Microtubule-Associated Proteins Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Cell Year: 2019 Document type: Article Affiliation country: United States

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