Diphenyliodonium Ion/Et3N Promoted Csp2-H Radical Phosphorylation of Enamides.
Org Lett
; 21(14): 5621-5625, 2019 07 19.
Article
in En
| MEDLINE
| ID: mdl-31257895
ABSTRACT
This work reports a simple and efficient method for the direct phosphorylation of enamide under metal-free conditions. The P-centered radicals, derived from secondary phosphine oxides, are generated under mild reaction conditions in the presence of diphenyliodonium salt and Et3N and are introduced onto a range of enamides in good isolated yields. The method features broad substrate scope, good functional group tolerance, and efficient scale-up.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2019
Document type:
Article
Affiliation country:
France