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mTORC1 to AMPK switching underlies ß-cell metabolic plasticity during maturation and diabetes.
Jaafar, Rami; Tran, Stella; Shah, Ajit N; Sun, Gao; Valdearcos, Martin; Marchetti, Piero; Masini, Matilde; Swisa, Avital; Giacometti, Simone; Bernal-Mizrachi, Ernesto; Matveyenko, Aleksey; Hebrok, Matthias; Dor, Yuval; Rutter, Guy A; Koliwad, Suneil K; Bhushan, Anil.
Affiliation
  • Jaafar R; The Diabetes Center, UCSF, San Francisco, California, USA.
  • Tran S; The Diabetes Center, UCSF, San Francisco, California, USA.
  • Shah AN; The Diabetes Center, UCSF, San Francisco, California, USA.
  • Sun G; Section of Cell Biology and Functional Genomics, Department of Medicine, Imperial College London, Hammersmith Hospital London, United Kingdom.
  • Valdearcos M; The Diabetes Center, UCSF, San Francisco, California, USA.
  • Marchetti P; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
  • Masini M; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
  • Swisa A; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
  • Giacometti S; The Diabetes Center, UCSF, San Francisco, California, USA.
  • Bernal-Mizrachi E; Division of Endocrinology, Diabetes and Metabolism, University of Miami, Miller School of Medicine, Miami, Florida, USA.
  • Matveyenko A; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.
  • Hebrok M; The Diabetes Center, UCSF, San Francisco, California, USA.
  • Dor Y; Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
  • Rutter GA; Section of Cell Biology and Functional Genomics, Department of Medicine, Imperial College London, Hammersmith Hospital London, United Kingdom.
  • Koliwad SK; The Diabetes Center, UCSF, San Francisco, California, USA.
  • Bhushan A; The Diabetes Center, UCSF, San Francisco, California, USA.
J Clin Invest ; 129(10): 4124-4137, 2019 07 02.
Article in En | MEDLINE | ID: mdl-31265435
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Diabetes Mellitus, Experimental / Diabetes Mellitus, Type 2 / Insulin-Secreting Cells / AMP-Activated Protein Kinases / Mechanistic Target of Rapamycin Complex 1 Limits: Animals Language: En Journal: J Clin Invest Year: 2019 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Diabetes Mellitus, Experimental / Diabetes Mellitus, Type 2 / Insulin-Secreting Cells / AMP-Activated Protein Kinases / Mechanistic Target of Rapamycin Complex 1 Limits: Animals Language: En Journal: J Clin Invest Year: 2019 Document type: Article Affiliation country: United States Country of publication: United States