Probing the interaction of a coumarin-di(2-picolyl)amine hybrid drug-like molecular entity with human serum albumin: Multiple spectroscopic and molecular modeling techniques.

Khan, Saman; Zafar, Atif; Naseem, Imrana

Khan, Saman; Zafar, Atif; Naseem, Imrana.

Affiliation

Khan S; Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, Uttar Pradesh, India.
Zafar A; Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, Uttar Pradesh, India.
Naseem I; Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, Uttar Pradesh, India. Electronic address: imrananaseem2009@gmail.com.

Spectrochim Acta A Mol Biomol Spectrosc ; 223: 117330, 2019 Dec 05.

Article in En | MEDLINE | ID: mdl-31280128

Subject(s)

Aminocoumarins/chemistry; Coumarins/chemistry; Models, Molecular; Serum Albumin, Human/chemistry; Spectrum Analysis; Binding Sites; Calorimetry; Circular Dichroism; Esterases/metabolism; Humans; Kinetics; Ligands; Molecular Docking Simulation; Protein Binding; Protein Carbonylation; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Thermodynamics

Key words

Cancer; Coumarin; Docking; HSA; Pharmacokinetic; Spectroscopy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spectrum Analysis / Models, Molecular / Coumarins / Aminocoumarins / Serum Albumin, Human Limits: Humans Language: En Journal: Spectrochim Acta A Mol Biomol Spectrosc Journal subject: BIOLOGIA MOLECULAR Year: 2019 Document type: Article Affiliation country: India Country of publication: United kingdom

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