Immunological implications of epidermal growth factor receptor signaling in persistent infections.
IUBMB Life
; 71(11): 1661-1671, 2019 11.
Article
in En
| MEDLINE
| ID: mdl-31283086
ABSTRACT
Infectious diseases account for a large proportion of global health emergencies and are rising more so owing to the paucity of effective vaccination and chemotherapeutic strategies. The severity is compounded by the development of antibiotic resistance among major pathogenic strains, capable of residing in the hostile host microenvironment by hijacking its signaling mechanisms and molecular circuitry. Among such processes, studies on epidermal growth factor receptor (EGFR) have revealed specific contributions of this classical oncogenic signaling axis during distinct infection conditions. Here, we review the current status of EGFR family members in the context of host-pathogen interactions and speculate the possible dimensions of exploration and manipulation of the EGFR pathway for host-directed therapeutic purposes.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Signal Transduction
/
Drug Resistance, Neoplasm
/
Host-Pathogen Interactions
/
Infections
/
Anti-Infective Agents
Type of study:
Etiology_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
IUBMB Life
Journal subject:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Year:
2019
Document type:
Article
Affiliation country:
India