Crossroads of Antibiotic Resistance and Biosynthesis.
J Mol Biol
; 431(18): 3370-3399, 2019 08 23.
Article
in En
| MEDLINE
| ID: mdl-31288031
ABSTRACT
The biosynthesis of antibiotics and self-protection mechanisms employed by antibiotic producers are an integral part of the growing antibiotic resistance threat. The origins of clinically relevant antibiotic resistance genes found in human pathogens have been traced to ancient microbial producers of antibiotics in natural environments. Widespread and frequent antibiotic use amplifies environmental pools of antibiotic resistance genes and increases the likelihood for the selection of a resistance event in human pathogens. This perspective will provide an overview of the origins of antibiotic resistance to highlight the crossroads of antibiotic biosynthesis and producer self-protection that result in clinically relevant resistance mechanisms. Some case studies of synergistic antibiotic combinations, adjuvants, and hybrid antibiotics will also be presented to show how native antibiotic producers manage the emergence of antibiotic resistance.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drug Resistance, Microbial
/
Anti-Bacterial Agents
Limits:
Animals
/
Humans
Language:
En
Journal:
J Mol Biol
Year:
2019
Document type:
Article