Decreasing the immunogenicity of Erwinia chrysanthemi asparaginase via protein engineering: computational approach.

Yari, Maryam; Eslami, Mahboobeh; Ghoshoon, Mohammad Bagher; Nezafat, Navid; Ghasemi, Younes

Yari, Maryam; Eslami, Mahboobeh; Ghoshoon, Mohammad Bagher; Nezafat, Navid; Ghasemi, Younes.

Affiliation

Yari M; Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
Eslami M; Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Ghoshoon MB; Pharmaceutical Science Research Center, Shiraz University of Medical Science, Shiraz, Iran.
Nezafat N; Pharmaceutical Science Research Center, Shiraz University of Medical Science, Shiraz, Iran.
Ghasemi Y; Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Mol Biol Rep ; 46(5): 4751-4761, 2019 Oct.

Article in En | MEDLINE | ID: mdl-31290058

Subject(s)

Asparaginase/immunology; Dickeya chrysanthemi/enzymology; Dickeya chrysanthemi/immunology; Protein Engineering; Asparaginase/chemistry; Asparaginase/genetics; Computational Biology/methods; Dickeya chrysanthemi/genetics; Epitopes, B-Lymphocyte/chemistry; Epitopes, B-Lymphocyte/genetics; Epitopes, B-Lymphocyte/immunology; Hydrophobic and Hydrophilic Interactions; Molecular Conformation; Molecular Dynamics Simulation; Mutation; Protein Stability; Recombinant Proteins; Structure-Activity Relationship

Key words

Asparaginase; B cell epitope; Bioinformatics; Immunogenicity; Therapeutic protein

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asparaginase / Protein Engineering / Dickeya chrysanthemi Type of study: Prognostic_studies Language: En Journal: Mol Biol Rep Year: 2019 Document type: Article Affiliation country: Iran Country of publication: Netherlands

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