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Small Cell Lung Cancer Derived from Adenocarcinoma with Mutant Epidermal Growth Factor Receptor Provides a Signature of Transcriptional Alteration in Tumor Cells.
Tenjin, Yuki; Nakamura, Kazuyoshi; Ishizuka, Shiho; Saruwatari, Koichi; Sato, Ryo; Tomita, Yusuke; Saeki, Sho; Ichiyasu, Hidenori; Fujii, Kazuhiko; Ito, Takaaki; Sakagami, Takuro.
Affiliation
  • Tenjin Y; Department of Respiratory Medicine, Faculty of Life Sciences, Graduate School of Medical Science, Kumamoto University, Japan.
  • Nakamura K; Departments of Pathology and Experimental Medicine, Faculty of Life Sciences, Graduate School of Medical Science, Kumamoto University, Japan.
  • Ishizuka S; Department of Respiratory Medicine, Faculty of Life Sciences, Graduate School of Medical Science, Kumamoto University, Japan.
  • Saruwatari K; Department of Respiratory Medicine, Faculty of Life Sciences, Graduate School of Medical Science, Kumamoto University, Japan.
  • Sato R; Department of Respiratory Medicine, Faculty of Life Sciences, Graduate School of Medical Science, Kumamoto University, Japan.
  • Tomita Y; Department of Respiratory Medicine, Faculty of Life Sciences, Graduate School of Medical Science, Kumamoto University, Japan.
  • Saeki S; Department of Respiratory Medicine, Faculty of Life Sciences, Graduate School of Medical Science, Kumamoto University, Japan.
  • Ichiyasu H; Department of Respiratory Medicine, Faculty of Life Sciences, Graduate School of Medical Science, Kumamoto University, Japan.
  • Fujii K; Department of Respiratory Medicine, Faculty of Life Sciences, Graduate School of Medical Science, Kumamoto University, Japan.
  • Ito T; Department of Respiratory Medicine, Faculty of Life Sciences, Graduate School of Medical Science, Kumamoto University, Japan.
  • Sakagami T; Departments of Pathology and Experimental Medicine, Faculty of Life Sciences, Graduate School of Medical Science, Kumamoto University, Japan.
Intern Med ; 58(22): 3261-3265, 2019 Nov 15.
Article in En | MEDLINE | ID: mdl-31292388
ABSTRACT
Small cell lung cancer (SCLC) transformation of epidermal growth factor receptor (EGFR) mutant adenocarcinoma (ADC) during EGFR tyrosine kinase inhibitor (TKI) treatment is an example of a rare subset of acquired drug resistance. We herein report the case of a 75-year-old man treated with afatinib who was then diagnosed with SCLC transformation. After two years of successful treatment with afatinib, the tumor relapsed, and a re-biopsy revealed SCLC harboring EGFR exon 19 deletion. We encountered a case of transcriptional alteration, potentially important for SCLC transformation of EGFR mutant lung ADC, that was recognized via the expression of NOTCH, ASCL1 and RB1 on immunohistochemical staining.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Resistance, Neoplasm / Small Cell Lung Carcinoma / ErbB Receptors / Adenocarcinoma of Lung / Lung Neoplasms Limits: Aged / Female / Humans / Male Language: En Journal: Intern Med Journal subject: MEDICINA INTERNA Year: 2019 Document type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Resistance, Neoplasm / Small Cell Lung Carcinoma / ErbB Receptors / Adenocarcinoma of Lung / Lung Neoplasms Limits: Aged / Female / Humans / Male Language: En Journal: Intern Med Journal subject: MEDICINA INTERNA Year: 2019 Document type: Article Affiliation country: Japan