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AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins.
Saline, Maria; Badertscher, Lukas; Wolter, Madita; Lau, Roxanne; Gunnarsson, Anders; Jacso, Tomas; Norris, Tyrrell; Ottmann, Christian; Snijder, Arjan.
Affiliation
  • Saline M; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
  • Badertscher L; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
  • Wolter M; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology and Institute for Complex Molecular Systems, Eindhoven University of Technology, P. O. Box 513, 5600 MB Eindhoven, The Netherlands.
  • Lau R; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology and Institute for Complex Molecular Systems, Eindhoven University of Technology, P. O. Box 513, 5600 MB Eindhoven, The Netherlands.
  • Gunnarsson A; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
  • Jacso T; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
  • Norris T; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
  • Ottmann C; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology and Institute for Complex Molecular Systems, Eindhoven University of Technology, P. O. Box 513, 5600 MB Eindhoven, The Netherlands.
  • Snijder A; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden. Electronic address: arjan.snijder@astrazeneca.com.
J Biol Chem ; 294(35): 13106-13116, 2019 08 30.
Article in En | MEDLINE | ID: mdl-31308176
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: 14-3-3 Proteins / Proto-Oncogene Proteins c-akt / AMP-Activated Protein Kinases / Forkhead Box Protein O1 Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2019 Document type: Article Affiliation country: Sweden Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: 14-3-3 Proteins / Proto-Oncogene Proteins c-akt / AMP-Activated Protein Kinases / Forkhead Box Protein O1 Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2019 Document type: Article Affiliation country: Sweden Country of publication: United States