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Rifampicin induces clathrin-dependent endocytosis and ubiquitin-proteasome degradation of MRP2 via oxidative stress-activated PKC-ERK/JNK/p38 and PI3K signaling pathways in HepG2 cells.
Xu, Bao-Yan; Tang, Xu-Dong; Chen, Jing; Wu, Hong-Bo; Chen, Wen-Sheng; Chen, Lei.
Affiliation
  • Xu BY; Department of Infectious Disease, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
  • Tang XD; Institute of Gastroenterology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
  • Chen J; Institute of Gastroenterology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
  • Wu HB; Institute of Gastroenterology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
  • Chen WS; Institute of Gastroenterology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
  • Chen L; Institute of Gastroenterology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China. 13883895566@163.com.
Acta Pharmacol Sin ; 41(1): 56-64, 2020 Jan.
Article in En | MEDLINE | ID: mdl-31316180
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rifampin / Signal Transduction / Clathrin / Oxidative Stress / Multidrug Resistance-Associated Proteins / Ubiquitin / Proteasome Endopeptidase Complex / Endocytosis Limits: Humans Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2020 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rifampin / Signal Transduction / Clathrin / Oxidative Stress / Multidrug Resistance-Associated Proteins / Ubiquitin / Proteasome Endopeptidase Complex / Endocytosis Limits: Humans Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2020 Document type: Article Affiliation country: China