TLR9-1486C/T polymorphism is associated with hepatocellular carcinoma recurrence after liver transplantation.
Biomark Med
; 13(12): 995-1004, 2019 08.
Article
in En
| MEDLINE
| ID: mdl-31317790
ABSTRACT
Aim:
To determine whether TLR9 polymorphisms are associated with tumor recurrence after liver transplantation for hepatocellular carcinoma (HCC). Patients &methods:
All patients who underwent liver transplantation, and had viable HCC in the explanted liver were included. TLR9-1237C/T and -1486C/T polymorphisms were analyzed by real-time PCR and melting curves analysis.Results:
20 of 159 patients (12.6%) developed post-transplant HCC recurrence. Tumors exceeding Milan criteria, moderately-to-poorly differentiated tumors and microvascular invasion on explants, and pretransplant α-fetoprotein level (all p < 0.01) were associated with an increased risk, while TLR9-1486TT genotype was associated with a decreased risk of HCC recurrence (p = 0.03).Conclusion:
TLR9-1486C/T might help to preoperatively identify patients at low risk of post-transplant HCC recurrence.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinoma, Hepatocellular
/
Toll-Like Receptor 9
/
Liver Neoplasms
/
Neoplasm Recurrence, Local
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Biomark Med
Journal subject:
BIOQUIMICA
/
MEDICINA
Year:
2019
Document type:
Article
Affiliation country:
Spain