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Highly selective and wash-free visualization of resistant bacteria with a relebactam-derived fluorogenic probe.
Chen, Yefeng; Xu, Minqiu; Xu, Weipan; Song, Heng; Hu, Liqiang; Xue, Shuyuan; Zhang, Shuangzhan; Qian, Xiana; Xie, Hexin.
Affiliation
  • Chen Y; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. xiehexin@ecust.edu.cn.
  • Xu M; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. xiehexin@ecust.edu.cn.
  • Xu W; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. xiehexin@ecust.edu.cn.
  • Song H; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. xiehexin@ecust.edu.cn.
  • Hu L; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. xiehexin@ecust.edu.cn.
  • Xue S; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. xiehexin@ecust.edu.cn.
  • Zhang S; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. xiehexin@ecust.edu.cn.
  • Qian X; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. xiehexin@ecust.edu.cn.
  • Xie H; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. xiehexin@ecust.edu.cn.
Chem Commun (Camb) ; 55(67): 9919-9922, 2019 Aug 28.
Article in En | MEDLINE | ID: mdl-31328197
ABSTRACT
Reported herein is a relebactam-derived fluorogenic reagent for covalent labeling of serine ß-lactamases (SBLs), which are the major causes of bacterial resistance to ß-lactam antibiotics. This highly selective imaging reagent generates over 300-fold stronger near-infrared fluorescence signals upon covalently bonding to SBLs, allowing wash-free visualization of live antimicrobial-resistant bacteria.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Beta-Lactamases / Affinity Labels / Enterobacter cloacae / Azabicyclo Compounds / Beta-Lactamase Inhibitors / Fluorescent Dyes Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2019 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Beta-Lactamases / Affinity Labels / Enterobacter cloacae / Azabicyclo Compounds / Beta-Lactamase Inhibitors / Fluorescent Dyes Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2019 Document type: Article Affiliation country: China