Lose the lipid: renoprotection conferred by Gb3 synthase knockout.
Kidney Int
; 96(2): 270-272, 2019 08.
Article
in En
| MEDLINE
| ID: mdl-31331463
ABSTRACT
The ability of proximal tubule cells to internalize filtered proteins over a broad concentration range is essential for maintaining a protein-free urine but also renders these cells uniquely susceptible to cytotoxic damage. Morace et al. find that knockout of globotriaosylceramide synthase, an enzyme required for production of Gb3 and other members of the globo series of glycosphingolipids, impairs endocytic uptake of filtered proteins and preserves kidney function in mouse models of acute kidney injury.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Trihexosylceramides
/
Acute Kidney Injury
Limits:
Animals
Language:
En
Journal:
Kidney Int
Year:
2019
Document type:
Article
Affiliation country:
United States