Plants and Phytocompounds Active Against Bothrops Venoms.
Curr Top Med Chem
; 19(22): 2003-2031, 2019.
Article
in En
| MEDLINE
| ID: mdl-31340736
ABSTRACT
Snakebite envenomation is an important health problem in tropical countries, with severe human and social consequences. In Latin America, the Bothrops species constitute the main threat to humans, and the envenomation caused by these species quickly develops into severe local tissue damage, including swelling, hemorrhaging, myonecrosis, skin ulceration, and pain. The systemic effects of envenomation are usually neutralized by antivenom serum therapy, despite its intrinsic risks. However, neutralization of local tissue damage remains a challenge. To improve actual therapy, two major alternatives are proposed the rational design of new specific antibodies for most of the tissue damaging/ poor immunogenic toxins, or the search for new synthetic or natural compounds which are able to inhibit these toxins and complement the serum therapy. Natural compounds isolated from plants, mainly from those used in folk medicine to treat snakebite, are a good choice for finding new lead compounds to improve snakebite treatment and minimize its consequences for the victims. In this article, we reviewed the most promising plants and phytocompounds active against bothropic venoms.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Snake Venoms
/
Biological Products
/
Antivenins
/
Plant Extracts
/
Phytochemicals
Limits:
Animals
/
Humans
Language:
En
Journal:
Curr Top Med Chem
Journal subject:
QUIMICA
Year:
2019
Document type:
Article
Affiliation country:
Brazil