High Prevalence of Developmental Venous Anomaly in Diffuse Intrinsic Pontine Gliomas: A Pediatric Control Study.
Neurosurgery
; 86(4): 517-523, 2020 04 01.
Article
in En
| MEDLINE
| ID: mdl-31342064
ABSTRACT
BACKGROUND:
No link has been demonstrated between diffuse intrinsic pontine glioma and developmental venous anomaly in pediatric patients.OBJECTIVE:
To determine the prevalence of developmental venous anomaly in a pediatric cohort of diffuse intrinsic pontine glioma.METHODS:
We performed a retrospective cohort study (1998-2017) of consecutive pediatric patients harboring a diffuse intrinsic pontine glioma (experimental set, n = 162) or a craniopharyngioma (control set, n = 142) in a tertiary pediatric neurosurgical center. The inclusion criteria were the following age <18 yr at diagnosis; histopathological diagnosis of diffuse intrinsic pontine glioma or craniopharyngioma according to the 2016 World Health Organization classification of tumors of the central nervous system; no previous oncological treatment; and available preoperative magnetic resonance imaging performed with similar acquisition protocol.RESULTS:
We found a significantly higher prevalence of developmental venous anomaly in the experimental set of 162 diffuse intrinsic pontine gliomas (24.1%) than in the control set of 142 craniopharyngiomas (10.6%; P = .001). The prevalence of developmental venous anomalies was not significantly impacted by demographic data (sex, age at diagnosis, and underlying pathological condition), biomolecular analysis (H3-K27M-mutant subgroup, H3.1-K27M-mutant subgroup, and H3.3-K27M-mutant subgroup), or imaging findings (anatomic location, anatomic extension, side, and obstructive hydrocephalus) of the studied diffuse intrinsic pontine gliomas.CONCLUSION:
We report a higher prevalence of developmental venous anomaly in pediatric diffuse intrinsic pontine glioma patients than in control patients, which suggests a potential underlying common predisposition or a causal relationship that will require deeper investigations.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Stem Neoplasms
/
Central Nervous System Vascular Malformations
/
Diffuse Intrinsic Pontine Glioma
Type of study:
Etiology_studies
/
Guideline
/
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Child
/
Female
/
Humans
/
Male
Language:
En
Journal:
Neurosurgery
Year:
2020
Document type:
Article
Affiliation country:
France