Insulin-like peptide 5 fails to improve metabolism or body weight in obese mice.
Peptides
; 120: 170116, 2019 10.
Article
in En
| MEDLINE
| ID: mdl-31348991
ABSTRACT
Insulin-like peptide 5 (INSL5) is a member of the insulin-like family of peptides. It has been reported to be orexigenic in rodent models of obesity with impaired glucose metabolism. We attempted to confirm this property as a first step in establishing the ability of INSL5 to successfully integrate with other agents more proven in their ability to reverse obesity and improve metabolism. INSL5 was chemically synthesized by two alternative methods to a native form and one that was site-specifically conjugated to a 20â¯KDa polyethylene glycol (PEG) polymer. The pharmacology of each peptide was assessed by high-dose chronic administration in normal and obese mice. INSL5 failed to produce pharmacologically relevant effects on food intake, body weight or glucose control indicative of a negligible role of the peptide in the control of feeding and glucose metabolism.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Body Weight
/
Peptide Hormones
/
Eating
/
Feeding Behavior
/
Glucose
/
Obesity
Limits:
Animals
Language:
En
Journal:
Peptides
Year:
2019
Document type:
Article