Lysine acetyltransferases and lysine deacetylases as targets for cardiovascular disease.
Nat Rev Cardiol
; 17(2): 96-115, 2020 02.
Article
in En
| MEDLINE
| ID: mdl-31350538
ABSTRACT
Lysine acetylation is a conserved, reversible, post-translational protein modification regulated by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs; also known as histone deacetylases (HDACs)) that is involved in many cellular signalling pathways and diseases. Studies in animal models have revealed a regulatory role of reversible lysine acetylation in hypertension, vascular diseases, arrhythmia, heart failure and angiogenesis. Evidence from these studies indicates a therapeutic role of KDAC inhibitors (also known as HDAC inhibitors) in cardiovascular diseases. In this Review, we describe the diverse roles of KATs and KDACs in both the normal and the diseased heart. Among KDACs, class II and class III HDACs seem to have a protective role against both cardiac damage and vessel injury, whereas class I HDACs protect against vessel injury but have deleterious effects on the heart. These observations have important implications for the clinical utility of HDAC inhibitors as therapeutic agents for cardiovascular diseases. In addition, we summarize the latest data on nonacetylation acylations in the context of cardiovascular disease.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cardiovascular Agents
/
Cardiovascular Diseases
/
Cardiovascular System
/
Protein Processing, Post-Translational
/
Histone Deacetylase Inhibitors
/
Lysine Acetyltransferases
/
Histone Deacetylases
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Nat Rev Cardiol
Journal subject:
CARDIOLOGIA
Year:
2020
Document type:
Article
Affiliation country:
China