Hyaluronic acid-functionalized gelatin hydrogels reveal extracellular matrix signals temper the efficacy of erlotinib against patient-derived glioblastoma specimens.

Pedron, Sara; Wolter, Gabrielle L; Chen, Jee-Wei E; Laken, Sarah E; Sarkaria, Jann N; Harley, Brendan A C

Pedron, Sara; Wolter, Gabrielle L; Chen, Jee-Wei E; Laken, Sarah E; Sarkaria, Jann N; Harley, Brendan A C.

Affiliation

Pedron S; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, IL, USA.
Wolter GL; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, IL, USA.
Chen JE; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, IL, USA.
Laken SE; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, IL, USA.
Sarkaria JN; Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA.
Harley BAC; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, IL, USA; Dept. of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, IL, USA. Electronic address: bharley@illinois.edu.

Biomaterials ; 219: 119371, 2019 10.

Article in En | MEDLINE | ID: mdl-31352310

Subject(s)

Brain Neoplasms/drug therapy; Erlotinib Hydrochloride/therapeutic use; Extracellular Matrix/metabolism; Gelatin/chemistry; Glioblastoma/drug therapy; Hyaluronic Acid/chemistry; Hydrogels/chemistry; Animals; Cell Line, Tumor; Cell Movement/drug effects; Cell Proliferation/drug effects; Cell Survival/drug effects; ErbB Receptors/metabolism; Erlotinib Hydrochloride/pharmacology; Humans; Hyaluronan Receptors/metabolism; Mice; Neoplasm Invasiveness; Receptor, Platelet-Derived Growth Factor beta/metabolism; STAT3 Transcription Factor/metabolism; Signal Transduction/drug effects; Treatment Outcome; Tumor Microenvironment/drug effects; Up-Regulation/drug effects

Key words

Drug resistance; Glioblastoma in vitro model; Hyaluronic acid; Hydrogel; Tumor microenvironment

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Glioblastoma / Hydrogels / Extracellular Matrix / Erlotinib Hydrochloride / Gelatin / Hyaluronic Acid Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Biomaterials Year: 2019 Document type: Article Affiliation country: United States Country of publication: Netherlands

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