Corticosteroids significantly increase cystatin C levels in the plasma by promoting cystatin C production in rats.
Ren Fail
; 41(1): 698-703, 2019 Nov.
Article
in En
| MEDLINE
| ID: mdl-31352865
ABSTRACT
Background:
Several studies have shown that non-renal factors such as corticosteroids may increase plasma cystatin C levels without affecting kidney function. However, the mechanisms underlying this are unclear. We hypothesized that corticosteroids may increase cystatin C levels in the plasma by promoting its production in tissues. In the present study, we aimed to test our hypothesis in rats by investigating the effect of corticosteroids on cystatin C production in tissues and the glomerular filtration rate (GFR), as measured by the gold standard method (i.e., inulin clearance).Results:
Dexamethasone treatment was associated with much higher concentrations of cystatin C in all organ tissue homogenates tested. Dexamethasone increased plasma cystatin C levels in rats, without any decrease in renal inulin clearance. The impact of dexamethasone on plasma and organ tissue cystatin C levels was abolished by RU486, indicating the effect was glucocorticoid receptor-mediated.Conclusions:
Our study provides direct evidence that corticosteroids may increase cystatin C levels in the plasma by promoting its production, without any decrease in GFR.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dexamethasone
/
Adrenal Cortex Hormones
/
Cystatin C
Limits:
Animals
Language:
En
Journal:
Ren Fail
Journal subject:
NEFROLOGIA
Year:
2019
Document type:
Article
Affiliation country:
China