Injectable Self-Assembling Peptide Hydrogels for Tissue Writing and Embryonic Stem Cell Culture.
J Biomed Nanotechnol
; 14(4): 802-807, 2018 Apr 01.
Article
in En
| MEDLINE
| ID: mdl-31352954
ABSTRACT
The fabrication of extracellular matrix-mimic hydrogels that can nurture and direct differentiation of embryonic stem cells is an important target for pattern-printed tissue replacement. Another desirable feature for such materials is their ability to be injected and recover their rheological features post-injection, allowing for facile non-invasive implantation. In this report, we demonstrate the ability of a self-assembling peptide hydrogel to support the culture of embryonic stem cells with the potential to direct differentiation. We also show that we can write a functional tissue replacement with a predetermined pattern using our formulation. Our results may lead to in vivo replacement of diseased tissue with a spatially resolved pattern of a regenerative hydrogel.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Embryonic Stem Cells
Language:
En
Journal:
J Biomed Nanotechnol
Year:
2018
Document type:
Article