Use of levosimendan in acute and advanced heart failure: short review on available real-world data.
Ther Clin Risk Manag
; 15: 765-772, 2019.
Article
in En
| MEDLINE
| ID: mdl-31354283
ABSTRACT
Published data have shown potential advantages of levosimendan in the management of acute decompensated heart failure and advanced heart failure when standard medical therapies threaten hemodynamics and organ perfusion are unable to alleviate clinical symptoms. Levosimendan distinguishes itself from other catecholaminergic inotropes by its three mechanisms of action positive inotropy, vasodilation, and cardioprotection. In addition, its pharmacokinetics allow for a longer duration of action from the metabolite OR1896 allowing for further cardiovascular therapeutic effects for several days, even after discontinuation of the parent drug.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Ther Clin Risk Manag
Year:
2019
Document type:
Article
Affiliation country:
United States