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Cryo-EM structure of TRPC5 at 2.8-Å resolution reveals unique and conserved structural elements essential for channel function.
Duan, Jingjing; Li, Jian; Chen, Gui-Lan; Ge, Yan; Liu, Jieyu; Xie, Kechen; Peng, Xiaogang; Zhou, Wei; Zhong, Jianing; Zhang, Yixing; Xu, Jie; Xue, Changhu; Liang, Bo; Zhu, Lan; Liu, Wei; Zhang, Cheng; Tian, Xiao-Li; Wang, Jianbin; Clapham, David E; Zeng, Bo; Li, Zongli; Zhang, Jin.
Affiliation
  • Duan J; Human Aging Research Institute (HARI), School of Life Sciences, Nanchang University, Nanchang, Jiangxi 330031, China.
  • Li J; School of Basic Medical Sciences, Nanchang University, Nanchang, Jiangxi 330031, China.
  • Chen GL; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
  • Ge Y; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of the Ministry of Education, Gannan Medical University, Ganzhou 341000, China.
  • Liu J; College of Pharmaceutical Sciences, Gannan Medical University, #1 Yixueyuan Road, Ganzhou, Jiangxi 341000, China.
  • Xie K; Key Laboratory of Medical Electrophysiology, Ministry of Education and Sichuan Province and Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan 646000, China.
  • Peng X; Department of Endocrinology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China.
  • Zhou W; Key Laboratory of Medical Electrophysiology, Ministry of Education and Sichuan Province and Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan 646000, China.
  • Zhong J; Key Laboratory of Medical Electrophysiology, Ministry of Education and Sichuan Province and Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan 646000, China.
  • Zhang Y; Key Laboratory of Medical Electrophysiology, Ministry of Education and Sichuan Province and Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan 646000, China.
  • Xu J; Key Laboratory of Molecular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
  • Xue C; Key Laboratory of Molecular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
  • Liang B; College of Pharmaceutical Sciences, Gannan Medical University, #1 Yixueyuan Road, Ganzhou, Jiangxi 341000, China.
  • Zhu L; School of Basic Medical Sciences, Nanchang University, Nanchang, Jiangxi 330031, China.
  • Liu W; College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
  • Zhang C; College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
  • Tian XL; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.
  • Wang J; School of Molecular Sciences and Biodesign Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
  • Clapham DE; School of Molecular Sciences and Biodesign Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
  • Zeng B; Jiangxi Jmerry Biopharmaceutical Co. Ltd, Ganzhou, Jiangxi 341000, China.
  • Li Z; Human Aging Research Institute (HARI), School of Life Sciences, Nanchang University, Nanchang, Jiangxi 330031, China.
  • Zhang J; School of Basic Medical Sciences, Nanchang University, Nanchang, Jiangxi 330031, China.
Sci Adv ; 5(7): eaaw7935, 2019 07.
Article in En | MEDLINE | ID: mdl-31355338
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Conserved Sequence / Cryoelectron Microscopy / TRPC Cation Channels Limits: Animals / Humans Language: En Journal: Sci Adv Year: 2019 Document type: Article Affiliation country: China Country of publication: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Conserved Sequence / Cryoelectron Microscopy / TRPC Cation Channels Limits: Animals / Humans Language: En Journal: Sci Adv Year: 2019 Document type: Article Affiliation country: China Country of publication: United States