Chagas disease in the Bolivian Chaco: Persistent transmission indicated by childhood seroscreening study.
Int J Infect Dis
; 86: 175-177, 2019 Sep.
Article
in En
| MEDLINE
| ID: mdl-31357060
ABSTRACT
BACKGROUND:
Screening for Trypanosoma cruzi infection was performed amongst children in a rural community in the Bolivian Chaco, an area known for high prevalence. The force of infection (FOI) was estimated.METHODS:
A total of 423 children attending the local school were screened using the Chagas Detect Plus (CDP) rapid test (InBios International, Inc.). CDP-positive specimens were further tested by indirect haemagglutination assay (IHA) and Wiener Recombinante v3.0 ELISA. A catalytic model was used to estimate FOI.RESULTS:
Confirmed seroprevalence was 0.22, rising steeply with age. The mean age of seropositive individuals was 13 years. The calculated specificity of the rapid test was 91.9%. The annual incidence estimated from the FOI was 0.021.CONCLUSIONS:
This study demonstrates persistent transmission and continuing high levels of T. cruzi infection in the Bolivian Chaco, and highlights the practicality of school-based screening.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chagas Disease
Type of study:
Diagnostic_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Country/Region as subject:
America do sul
/
Bolivia
Language:
En
Journal:
Int J Infect Dis
Journal subject:
DOENCAS TRANSMISSIVEIS
Year:
2019
Document type:
Article