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The antibody-based delivery of interleukin-12 to solid tumors boosts NK and CD8+ T cell activity and synergizes with immune checkpoint inhibitors.
Puca, Emanuele; Probst, Philipp; Stringhini, Marco; Murer, Patrizia; Pellegrini, Giovanni; Cazzamalli, Samuele; Hutmacher, Cornelia; Gouyou, Baptiste; Wulhfard, Sarah; Matasci, Mattia; Villa, Alessandra; Neri, Dario.
Affiliation
  • Puca E; Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Zürich, Switzerland.
  • Probst P; Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Zürich, Switzerland.
  • Stringhini M; Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Zürich, Switzerland.
  • Murer P; Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Zürich, Switzerland.
  • Pellegrini G; Laboratory for Animal Model Pathology, Universität Zürich, Zürich, Switzerland.
  • Cazzamalli S; Philochem AG, Otelfingen, Switzerland.
  • Hutmacher C; Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Zürich, Switzerland.
  • Gouyou B; Philochem AG, Otelfingen, Switzerland.
  • Wulhfard S; Philochem AG, Otelfingen, Switzerland.
  • Matasci M; Philochem AG, Otelfingen, Switzerland.
  • Villa A; Philochem AG, Otelfingen, Switzerland.
  • Neri D; Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Zürich, Switzerland.
Int J Cancer ; 146(9): 2518-2530, 2020 05 01.
Article in En | MEDLINE | ID: mdl-31374124
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Killer Cells, Natural / Colonic Neoplasms / Interleukin-12 / CD8-Positive T-Lymphocytes / Drug Synergism / Antineoplastic Agents, Immunological / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Int J Cancer Year: 2020 Document type: Article Affiliation country: Switzerland Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Killer Cells, Natural / Colonic Neoplasms / Interleukin-12 / CD8-Positive T-Lymphocytes / Drug Synergism / Antineoplastic Agents, Immunological / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Int J Cancer Year: 2020 Document type: Article Affiliation country: Switzerland Country of publication: United States