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Modeling Monogenic Diabetes using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A.
Cardenas-Diaz, Fabian L; Osorio-Quintero, Catherine; Diaz-Miranda, Maria A; Kishore, Siddharth; Leavens, Karla; Jobaliya, Chintan; Stanescu, Diana; Ortiz-Gonzalez, Xilma; Yoon, Christine; Chen, Christopher S; Haliyur, Rachana; Brissova, Marcela; Powers, Alvin C; French, Deborah L; Gadue, Paul.
Affiliation
  • Cardenas-Diaz FL; Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA.
  • Osorio-Quintero C; Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Diaz-Miranda MA; Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA.
  • Kishore S; Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Cell and Molecular Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Leavens K; Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, and Division of Endocrinology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Jobaliya C; Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Stanescu D; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, and Division of Endocrinology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Ortiz-Gonzalez X; Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Yoon C; Department of Biomedical Engineering, Boston University, Boston, MA, USA.
  • Chen CS; Department of Biomedical Engineering, Boston University, Boston, MA, USA; The Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.
  • Haliyur R; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.
  • Brissova M; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Powers AC; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA
  • French DL; Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Gadue P; Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. Electronic address: gaduep@email.chop.edu.
Cell Stem Cell ; 25(2): 273-289.e5, 2019 08 01.
Article in En | MEDLINE | ID: mdl-31374199
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreas / Diabetes Mellitus, Type 2 / Hepatocyte Nuclear Factor 1-alpha / Human Embryonic Stem Cells Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cell Stem Cell Year: 2019 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreas / Diabetes Mellitus, Type 2 / Hepatocyte Nuclear Factor 1-alpha / Human Embryonic Stem Cells Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cell Stem Cell Year: 2019 Document type: Article Affiliation country: United States Country of publication: United States