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Targeting the subpocket in xanthine oxidase: Design, synthesis, and biological evaluation of 2-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives.
Zhang, Bing; Dai, Xiwen; Bao, Ziyang; Mao, Qing; Duan, Yulin; Yang, Yuwei; Wang, Shaojie.
Affiliation
  • Zhang B; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang, 110016, China.
  • Dai X; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang, 110016, China.
  • Bao Z; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang, 110016, China.
  • Mao Q; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang, 110016, China.
  • Duan Y; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang, 110016, China.
  • Yang Y; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang, 110016, China.
  • Wang S; Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Culture Road, Shenhe District, Shenyang, 110016, China. Electronic address: sjwang_99@163.com.
Eur J Med Chem ; 181: 111559, 2019 Nov 01.
Article in En | MEDLINE | ID: mdl-31376568
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Xanthine Oxidase / Carboxylic Acids / Drug Design / Enzyme Inhibitors Limits: Animals Language: En Journal: Eur J Med Chem Year: 2019 Document type: Article Affiliation country: China Country of publication: France
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Xanthine Oxidase / Carboxylic Acids / Drug Design / Enzyme Inhibitors Limits: Animals Language: En Journal: Eur J Med Chem Year: 2019 Document type: Article Affiliation country: China Country of publication: France